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Proteins associated with autosomal dominant and autosomal recessive polycystic kidney disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular compartments, but their functional site is thought to be on primary cilia. PC1+ vesicles surround cilia in Pkhd1(del2/del2) mice, which led us to analyze these structures in detail. We(More)
Chronic liver disease is a world-wide problem that causes progressive hepatic fibrosis as a hallmark of progressive injury. At present, the gold standard for diagnosing hepatic fibrosis is liver biopsy, which is an invasive method with many limitations, including questionable accuracy and risks of complications. MR elastography (MRE), a phase-contrast MRI(More)
OBJECTIVES Functional blood oxygenation level-dependent (BOLD) magnetic resonance imaging is a powerful tool to assess renal function, but BOLD analysis using T2* image differentiation of cortex and medulla is laborious and prone to errors. We developed and validated an alternative compartmental analysis method to differentiate renal cortical and medullary(More)
(2012). Computing at school: an emergent community of practice for a re-emergent subject. Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Abstract The Computing at(More)
BACKGROUND Renovascular hypertension (RVH) is characterized by chronic inflammation of the stenotic kidney and progressive renal dysfunction. Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein induced in inflammatory conditions and ischemia, is a novel biomarker for acute kidney injury. We hypothesized that chronic RVH would be(More)
  • X.-Y Z, Cardiovascular Diseases, +13 authors Black Eh Patients
  • 2013
B lack individuals have a higher incidence and prevalence of essential hypertension (EH) compared with whites. 1 Furthermore, morbidity and mortality rates are higher in black EH compared with white EH patients. Over the past decade, factors suggested to explain this ethnic disparity included dietary habits, obesity, and insulin resistance. 4 Augmented(More)
OBJECTIVE To establish and characterize a novel domestic porcine model of obesity. METHODS Fourteen domestic pigs were fed normal (lean, n=7) or high-fat/high-fructose diet (obese, n=7) for 16 weeks. Subcutaneous abdominal adipose tissue biopsies were obtained after 8, 12, and 16 weeks of diet, and pericardial adipose tissue after 16 weeks, for(More)
Programming has been cited as a barrier for female students to enjoy and pursue computing as a career or at higher education. However, there are examples of good practice, which demonstrate that programming can act as a bridge rather than a barrier. As a result of surveying 103 students and interviewing 60 students from 3 different UK higher education(More)
When a child paints, when a child draws and when a child pastes they participate in Piagetian concrete activity. The activities are concrete because they are the combination of mental processing and physical activities. On the computer the situation is similar. The extent to which painting, drawing and pasting are concrete activities is reflected in the way(More)