John-William N Carroll

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Viral infections cause profound alterations in host cells. Here, we explore the interactions between proteins of the Alphavirus Sindbis and host factors during the course of mammalian cell infection. Using a mutant virus expressing the viral nsP3 protein tagged with green fluorescent protein (GFP) we directly observed nsP3 localization and isolated(More)
We are interested in characterizing the cellular machinery involved in the restriction of retrovirus replication-the components of the innate or ''intrinsic'' immunity. Studies of two such systems will be presented. In the first example, we have identified components involved in tran-scriptional silencing of proviral DNA by Embryonic Stem (ES) cells. It has(More)
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