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Ultrasonic measurements of human carotid and femoral artery walls are conventionally obtained by manually tracing interfaces between tissue layers. The drawbacks of this method are the interobserver variability and inefficiency. In this paper, we present a new automated method which reduces these problems. By applying a multiscale dynamic programming (DP)(More)
BACKGROUND It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins. METHODS AND FINDINGS We searched MEDLINE, EMBASE, and Cochrane CENTRAL up to March 2012 for randomised(More)
BACKGROUND AND PURPOSE Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to C(More)
AIMS To estimate the cost-effectiveness of 10 mg rosuvastatin daily for older patients with systolic heart failure in the Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) trial. METHODS AND RESULTS This within trial analysis of CORONA used major cardiovascular (CV) events as the outcome measure. Resource use was valued and the costs(More)
Recent genome-wide association studies have identified multiple loci that are associated with an increased risk of developing coronary artery disease (CAD). The impact of these loci on the disease severity and prognosis of ischemic heart failure due to CAD is currently unknown. We undertook association analysis of 7 single nucleotide polymorphism (rs599839,(More)
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