John Whitbeck

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We analyze the dynamics of a mobility dataset collected in a pipelined disruption-tolerant network (DTN), a particular class of intermittently-connected wireless networks characterized by a one-dimensional topology. First, we collected and investigated traces of contact times among a thousand participants of a rollerblading tour in Paris. The dataset shows(More)
Certain mutant strains of herpes simplex virus type 1 (HSV-1) are unable to infect cells in which entry is dependent on HVEM, the previously described herpesvirus entry mediator designated here as herpesvirus entry protein A (HveA). These mutant viruses can infect other cells where entry is apparently dependent on other co-receptors. The mutant virus(More)
Major wireless operators are nowadays facing network capacity issues in striving to meet the growing demands of mobile users. At the same time, 3G-enabled devices increasingly benefit from ad hoc radio connectivity (e.g., Wi-Fi). In this context of hybrid connectivity, we propose Push-and-track, a content dissemination framework that harnesses ad hoc(More)
Major wireless operators are nowadays facing network capacity issues in striving to meet the growing demands of mobile users. At the same time, 3G-enabled devices increasingly benefit from ad hoc radio connectivity (e.g., WiFi). In this context of hybrid connectivity, we propose Push-and-track, a content dissemination framework that harnesses ad hoc(More)
In this paper we propose HYMAD, a Hybrid DTN-MANET routing protocol which uses DTN between disjoint groups of nodes while using MANET routing within these groups. HYMAD is fully decentralized and only makes use of topological information exchanges between the nodes. We evaluate the scheme in simulation by replaying real life traces which exhibit this highly(More)
We analyze the dynamics of a mobility data set collected in a pipelined disruption-tolerant network (DTN), a particular class of intermittently-connected wireless networks characterized by a 1-D topology. First, we collected and investigated traces of contact times among thousands of participants of a rollerblading tour in Paris. The data set shows extreme(More)
LIGHT is a tumor necrosis factor (TNF) ligand superfamily member, which binds two known cellular receptors, lymphotoxin-beta receptor (LTbetaR) and the herpesvirus entry mediator (HveA). LIGHT is a homotrimer that activates proapoptotic and integrin-inducing pathways. Receptor binding residues via LIGHT were identified by introducing point mutations in the(More)
Glycoprotein B (gB), along with gD, gH, and gL, is essential for herpes simplex virus (HSV) entry. The crystal structure of the gB ectodomain revealed it to be an elongated multidomain trimer. We generated and characterized a panel of 67 monoclonal antibodies (MAbs). Eleven of the MAbs had virus-neutralizing activity. To organize gB into functional regions(More)
This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escherichia coli lacZ gene into the predicted gE(More)
Ebola virus exhibits a broad cellular tropism in vitro. In humans and animal models, virus is found in most tissues and organs during the latter stages of infection. In contrast, a more restricted cell and tissue tropism is exhibited early in infection where macrophages, liver, lymph node, and spleen are major initial targets. This indicates that cellular(More)