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Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beat-to-beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells originating from the same region of the same heart. However, current mathematical models of ventricular AP(More)
Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in human heart failure and atrial fibrillation, such as action potential (AP) prolongation, increased AP(More)
We study the wavefronts (i.e. the surfaces of constant phase) of the wave discussed by Aharonov and Bohm, representing a beam of particles with charge q scattered by an impenetrable cylinder of radius R containing magnetic flux @. Defining the quantum flux parameter by a = q@/h, we show that for the case R = 0 the wave I+%-possesses a wavefront dislocation(More)
Variability in the action potential of isolated myocytes and tissue samples is observed in experimental studies. Variability is manifested as both differences in the action potential (AP) morphology between cells (extrinsic variability), and also 'intrinsic' or beat-to-beat variability of repolarization (BVR) in the AP duration of each cell. We studied the(More)
Diatoms are an ecologically successful group within the phytoplankton, and their special feature is a biofabricated silica cell encasement called a frustule. These frustules attract interest in material technology, and one potential application is to use them in solar cell technology. The silica frustule with its nanoscaled pattern is interesting per se,(More)
Low energy ion-beam sputtering of GaSb results in self-organized nanostructures with the potential of structuring large surface areas. Characterization of such nanostructures by optical methods is studied and compared to direct (local) microscopic methods. The samples consist of densely packed GaSb cones on bulk GaSb, approximately 30, 50, and 300 nm in(More)
Cardiac electrical asynchrony occurs as a result of cardiac pacing or conduction disorders such as left bundle-branch block (LBBB). Electrically asynchronous activation causes myocardial contraction heterogeneity that can be detrimental for cardiac function. Computational models provide a tool for understanding pathological consequences of dyssynchronous(More)