John W. Wilkins

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HIV produces a chronic viral infection of the central nervous system that elicits chronic glial activation and overexpression of glial cytokines that are also implicated in Alzheimer disease (AD) pathogenesis. A genetic risk factor for AD is the E4 isoform for apolipoprotein E (APOE). Here we compare the frequency of neurologic symptoms for subjects with(More)
Atlantic coast estuaries recently have experienced fish kills and fish with lesions attributed to Pfiesteria piscicida and related dinoflagellates. Human health effects have been reported from laboratory exposure and from a 1997 Maryland fish kill. North Carolina has recorded Pfiesteria-related fish kill events over the past decade, but human health effects(More)
The combination of long-time, tight-binding molecular dynamics and real-time multiresolution analysis techniques reveals the complexity of small silicon interstitial defects. The stability of identified structures is confirmed by ab initio relaxations. The majority of structures were previously unknown, demonstrating the effectiveness of the approach. A(More)
To determine the relationship between neuroanatomic and neuropsychological changes in both asymptomatic and symptomatic HIV-1-infected individuals, we conducted a longitudinal study of 47 HIV-infected individuals, 15 of whom were asymptomatic and 32 of whom had either AIDS-related complex or AIDS. To measure neuroanatomic change over a 30-month period, we(More)
OBJECTIVE The authors examined HIV-positive subjects to determine the relationship of patient complaints of cognitive and motor dysfunction to psychiatric status and performance on established cognitive and motor function tests. METHOD HIV-positive volunteers (N = 77) were evaluated at entry into a longitudinal neurological study. Forty were asymptomatic,(More)
A cohort of 94 patients infected with human immunodeficiency virus was evaluated clinically and electrophysiologically for the presence of peripheral neuropathy, and the results were compared with evaluations of central nervous system function. Thirty-two (34%) had some degree of peripheral neuropathy; 18 (19%) (six [12%] of the 49 asymptomatic patients,(More)
Impurities control phase stability and phase transformations in natural and man-made materials, from shape-memory alloys to steel to planetary cores. Experiments and empirical databases are still central to tuning the impurity effects. What is missing is a broad theoretical underpinning. Consider, for example, the titanium martensitic transformations:(More)
Enrique R. Batista,1,* Jochen Heyd,2 Richard G. Hennig,3 Blas P. Uberuaga,4 Richard L. Martin,1 Gustavo E. Scuseria,2 C. J. Umrigar,5 and John W. Wilkins6 1Theoretical Division, Los Alamos National Laboratory, MS-B268, Los Alamos, New Mexico 87545, USA 2Department of Chemistry, Rice University, Houston, Texas 77005-1892, USA 3Department of Physics, Ohio(More)
sible supercells of and ! to determine the lattice strain exact energy barrier. The TB-NEB barrier is bounded Martensitic transformations are abundant in nature and are commonly used in engineering technologies [1]. Materials from steel to shape-memory alloys are governed by their underlying martensitic transformations [2]. The pressure driven hcp ! !(More)