John W. Shigeoka

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The effects of a four month aerobic exercise conditioning program on neuropsychological test performance, depression indices, sensory thresholds, and visual acuity of 55-70 year old sedentary individuals were evaluated. Aerobically trained subjects were compared with two age-matched control groups of subjects: those who trained with strength and flexibility(More)
Measures of EEG, event-related potentials (ERPs), visual sensitivity, and cognition were obtained from 30 young (20-31 years) and 30 older (50-62 years) healthy men. Age groups were evenly divided between subjects with low and high fitness levels documented by VO2max during a maximal exercise test. Age comparisons revealed that, compared to young adults,(More)
An increased incidence of intermediate deficiency of serum alpha1-antitrypsin resulting from Pi phenotype MZ has been reported in patients with chronic obstructive pulmonary disease (COPD) by some laboratories but not confirmed by others. Prevalence of Pi MZ was determined in patients with COPD among 502 subjects referred to a pulmonary function testing(More)
Five subjects (group 1) performed progressive treadmill exercise on 2 separate days, once while breathing room air (normoxemic) and the other time while breathing gas with a fractional inspired O2 of 17% (hypoxemic). Five other subjects (group 2) performed two progressive treadmill exercise tests on each of 2 separate days in a crossover design. On 1 day(More)
The concomitant occurrence of mercury emboli and thromboemboli of the lung has not been previously reported. We describe the case of an intravenous drug abuser with chest pain and newly discovered mercury emboli in the lung who was found to have a thromboembolus in the right pulmonary artery. An echocardiogram showed metallic density in the right ventricle,(More)
In view of recent reports of contamination of the fibreoptic bronchoscope by tuberculous and non-tuberculous mycobacteria, we evaluated the disinfecting properties of aqueous glutaraldehyde (Cidex) and an iodophor (Prepodyne) against Mycobacterium tuberculosis and M gordonae. We found that a 15 minute disinfection procedure with either agent, coupled with(More)
Largely on the basis of postmortem studies, pulmonary emboli have been implicated as an etiologic factor in the acute and chronic respiratory failure of chronic obstructive pulmonary disease (COPD). The diagnosis of pulmonary embolism clinically or by tests directed at the lungs (except pulmonary angiography) is likely to be inaccurate in the presence of(More)
We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally(More)
Physiological profiles are described for 30 healthy young (20-31 years) and 30 healthy older (50-62 years) men. Half of the individuals in each group reported that during the previous five years they participated frequently in strenuous physical exercises; the other half reported sedentary lifestyles. A treadmill exercise test was used to determine maximal(More)
Demand valves conserve oxygen by limiting delivery to the inspiratory phase of respiration and reducing the waste which occurs during expiration with conventional, constant flow therapy. However, arterial oxygen tensions (PaO2) achieved in past evaluations were frequently higher than recommended for treating chronic hypoxemia. We wondered if excessive(More)