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Between the acquisition of Evoked Potential (EP) data and their interpretation lies a major problem: What to measure? An approach to this kind of problem is outlined here in terms of Principal Components Analysis (PCA). An important second theme is that experimental manipulation is important to functional interpretation. It would be desirable to have a(More)
A pattern of components from brain event-related potentials (ERPs) (cognitive non-invasive electrical brain measures) performed well in separating early-stage Alzheimer's disease (AD) subjects from normal-aging control subjects and shows promise for developing a clinical diagnostic for probable AD. A Number-Letter task elicited brain activity related to(More)
An EP component with a poststimulus maximum about 250 msec, labeled the Storage Component , is interpreted to be related to the storage of stimulus information in short-term memory. It was obtained by Principal Components Analysis of Evoked Potentials in a letter/ number information processing experiment. The Storage Component appeared in a similar form in(More)
An evoked potential component with a poststimulus peak at about 250 milliseconds is related to the storage of information in short-term memory. This storage component was found in an investigation of brain potentials in relation to a number and letter comparison task. In replications of this experiment at three different light intensities spaced 1.0 log(More)
Evoked Potentials from electroencephalogram (EEG) recording were averaged to many visually presented word stimuli whose semantic meanings were specified along Osgood's semantic universals of affective meaning, Urbana, Ill.: University of Illinois Press]. Multivariate analyses classified the Evoked Potentials to six semantic classes with success rates more(More)
We analyzed verbal episodic memory learning and recall using the Logical Memory (LM) subtest of the Wechsler Memory Scale-III to determine how gender differences in AD compare to those seen in normal elderly and whether or not these differences impact assessment of AD. We administered the LM to both an AD and a Control group, each comprised of 21 men and 21(More)
The aim of this research was to assess similarity in cognitive factor structures underlying neuropsychological test performance of elders belonging to three clinical groups: Alzheimer's disease (AD), Mild Cognitive Impairment (MCI), and normal elderly. We administered a battery of neuropsychological tests to 214 elderly participants in the groups. First,(More)
Behavioral (semantic differential) and neural (Evoked Potentials, EPs) responses were related to connotative meaning. The approach was based on Os-good's semantic analyses and dimensions of Evaluation (E), Potency (P), and Activity (A). The experimental variables were (I) the semantic class of the stimulus word (E+, E-, P+ , P-, A+, A-) and (2) the(More)
Neuropsychological assessment aids in the diagnosis of Alzheimer's disease (AD) by objectively establishing cognitive impairment from standardized tests. We present new criteria for diagnosis that use weighted combined scores from multiple tests. Our method employs two multivariate analyses: principal components analysis (PCA) and discriminant analysis. PCA(More)
Predicting which individuals will progress to Alzheimer's disease (AD) is important in both clinical and research settings. We used brain Event-Related Potentials (ERPs) obtained in a perceptual/cognitive paradigm with various processing demands to predict which individual Mild Cognitive Impairment (MCI) subjects will develop AD versus which will not. ERP(More)