John W. Mayo

Learn More
A series of designed peptide 33-mers (betapep peptides) areknown to be bactericidal [Mayo, Haseman, Ilyina and Gray (1998)Biochim. Biophys. Acta 1425, 81-92]. Here dodecapeptides (SC-1-SC-8), which 'walk through' the sequence ofbetapep-25, were investigated for their ability to kill Gram-negativeand -positive bacteria and to neutralize endotoxin. SC-4(More)
The now standard principal-agent model of regulator-firm interactions typically assumes the presence of a single regulator and an exogenously determined information asymmetry between the principal and the agent. In this paper we draw upon a unique data set of regulatory inspections conducted by the U.S. Food and Drug Administration (FDA) to explore the(More)
Large sunk costs and incomplete regulatory contracts in public utilities create the possibility of opportunistic behavior by either regulators or regulated firms. We present an empirical methodology for identifying opportunism within a regulated setting, and apply it to the largescale cost disallowances levied by state regulators on electric utilities(More)
Growth of Aerobacter aerogenes PRL-R3 on the unnatural hexose l-mannose as a sole carbon source is dependent upon the selection of a mutant. Growth of the mutant on l-mannose did not require the synthesis of novel enzymes for the degradation of l-mannose, since enzymes of the l-rhamnose degradative pathway could serve this function. However, unlike most(More)
Prospective surveillance of hospitalized patients with leukemia or solid tumors was performed in order to define the rate of nosocomial bloodstream infection according to specific diagnosis. During the 38-month study, there were 842 nosocomial blood stream infections in 704 patients, 22% of whom had leukemia or solid tumors. In the patients with malignancy,(More)
Research produced by the Center is released subject to the quality of its methods and analysis and is not dependent upon any of the policy positions of current, previous or prospective Center supporters. A complete list of financial supporters that enable the activities of the Center is available on our website, These funders include,(More)
Existing models of cross-subsidization have focused on either ex ante distortions to investments or misallocations of common costs as the principal sources of crosssubsidies in regulated firms. In this paper, we identify a third vehicle for such cross-subsidization that, given regulators’ preferences, is not only likely but likely to be prominent; namely,(More)
The Staggers Rail Act of 1980 is widely perceived to have deregulated the U.S. freight rail industry. Yet substantial rail traffic remains potentially subject to regulatory rate intervention, and in the Post-Staggers era regulators have developed a detailed and expanding regulatory framework for rail shipments. This regulatory framework embodies elements of(More)
Policymakers generally hope to encourage competition, but often do not agree on what form competition should take. In network industries with high sunk costs and low marginal costs some believe that competition is best encouraged by requiring incumbent firms to allow entrants to use the incumbent’s infrastructure to offer competing services. Others argue(More)