John W. Frederick

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OBJECTIVES/HYPOTHESIS Define surgical outcomes of specific donor sites for free tissue transfer in head and neck reconstruction. STUDY DESIGN Retrospective cohort review at an academic tertiary care center. METHODS A review was made of free tissue transfer procedures performed at a university-based tertiary care facility from October 2004 to April 2011.(More)
IMPORTANCE As new institutions incorporate transoral robotic surgery (TORS) into their everyday practice, it is helpful to have a timeline reference of expected goals to follow as their experience increases. This article evaluates a single tertiary care academic institution's experience with TORS for head and neck tumors and reports its 4-year learning(More)
BACKGROUND CD147 is upregulated in multiple cancer types, but its expression in advanced cutaneous squamous cell carcinoma (SCC) is unknown. Our purpose was to evaluate the expression patterns of CD147 and related monocarboxylate transporters (MCT1, MCT4) to determine their correlation with survival. METHODS This is a retrospective cohort study of(More)
BACKGROUND Retromaxillary air cells (RMC) are posterior ethmoid cells that separate the maxillary and ethmoid sinuses. The clinical significance of these cells in contributing to revision functional endoscopic sinus surgery (FESS) is unknown. OBJECTIVES To investigate the prevalence, anatomic dimensions, and radiographic characteristics of RMC in patients(More)
OBJECTIVE To assess the advantages of using mechanical anastomotic systems in head and neck free tissue transfer. STUDY DESIGN Case series with chart review. SETTING A university-based tertiary care center. SUBJECTS AND METHODS A retrospective review of mechanical venous coupler devices in head and neck reconstruction performed between October 2004(More)
BACKGROUND Inverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy(More)
BACKGROUND Advanced cutaneous squamous cell carcinoma (SCC) is an uncommon and aggressive malignancy. As a result, there is limited understanding of its biology and pathogenesis. CD147 and epidermal growth factor receptor (EGFR) have been identified as oncologically important targets, but their relationship remains undefined in cutaneous SCC. METHODS(More)
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