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Journals and Conferences
The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies in normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets and osmotic pumps) were administered with different amounts of food in the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by… (More)
Isolated mesenteric arteries, studied under 25-30 mg resting tension, responded to prolonged noradrenaline or electrical stimulation with a 50-500 mg increase in tension from which they subsequently escaped towards resting tension levels.
To elucidate the role of the small bowel and liver in sulfasalazine (SASP) metabolism, we performed studies in patients, cats, and rats. The role of the small bowel in absorption and metabolism of SASP was determined by the amount of administered SASP excreted in ileostomy effluents, and the concentration of serum and urinary SASP and its metabolites,… (More)
The relative blood flow distribution within the small intestine of anesthetized cats was investigated during resting conditions and when superior mesenteric blood flow was increased 15--85% by the intravenous infusion of secretin, cholecystokinin (CCK), or isoproterenol. Radioactive microspheres of 15 mum diameter were injected into the superior mesenteric… (More)
This study demonstrates that for the isolated cat gall bladder a smaller molar dose of the sulfated form of OP-CCK and gastrin is required to produce contraction as compared to the respective non-sulfated forms. For OP the D50 for the sulfated form versus the non-sulfated form was 1.94. For gastrin it was 1.10.
The superior mesenteric blood flow response to intra-arterial injections (0.5-25 mug) and infusions (5-30 mug/min) of 5-hydroxytryptamine (5-HT, serotonin) was investigated in anesthetized cats in which nerve activity to the intestine was altered by surgical and pharmacological procedures. With the superior mesenteric periarterial nerves intact, low doses… (More)