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OBJECTIVE To examine the relationship between total parenteral nutrition(TPN) and complication and death rates in surgical patients. DATA SOURCES A computer search of published research on MEDLINE, personal files and a review of relevant reference lists. STUDY SELECTION A review of 237 titles, abstracts or papers. Primary studies were included if they(More)
CONTEXT Several nutrients have been shown to influence immunologic and inflammatory responses in humans. Whether these effects translate into an improvement in clinical outcomes in critically ill patients remains unclear. OBJECTIVE To examine the relationship between enteral nutrition supplemented with immune-enhancing nutrients and infectious(More)
INTRODUCTION The purpose of this pilot study is to assess the feasibility, acceptability, and safety of a new feeding protocol designed to enhance the delivery of enteral nutrition (EN). METHODS In a prospective before and after study, we evaluated a new protocol compared to our standard feeding protocol. Innovative elements of the new protocol included(More)
INTRODUCTION Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in critical care so that more definitive high quality RCTs can be completed with the available resources. The objective of this study was to(More)
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