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CONTEXT Several nutrients have been shown to influence immunologic and inflammatory responses in humans. Whether these effects translate into an improvement in clinical outcomes in critically ill patients remains unclear. OBJECTIVE To examine the relationship between enteral nutrition supplemented with immune-enhancing nutrients and infectious(More)
PURPOSE To test discrimination and calibration of APACHE-II and SAPS-II risk prediction scores in a cohort of obstetric patients, and to evaluate the effect of modifying these scores for the physiological changes in pregnancy. MATERIALS AND METHODS A retrospective review of obstetric patients, 12 weeks gestation to 48 hours postpartum, admitted to the ICU(More)
OBJECTIVE To examine the relationship between total parenteral nutrition(TPN) and complication and death rates in surgical patients. DATA SOURCES A computer search of published research on MEDLINE, personal files and a review of relevant reference lists. STUDY SELECTION A review of 237 titles, abstracts or papers. Primary studies were included if they(More)
OBJECTIVE This study was conducted to develop evidence-based clinical practice guidelines for nutrition support (ie, enteral and parenteral nutrition) in mechanically ventilated critically ill adults. OPTIONS The following interventions were systematically reviewed for inclusion in the guidelines: enteral nutrition (EN) versus parenteral nutrition (PN),(More)
OBJECTIVE To examine the relationship between glutamine supplementation and hospital length of stay, complication rates, and mortality in patients undergoing surgery and experiencing critical illness. DATA SOURCES Computerized search of electronic databases and search of personal files, abstract proceedings, relevant journals, and review of reference(More)
CONTEXT Nutritional support has become a standard of care for hospitalized patients, but whether total parenteral nutrition (TPN) affects morbidity and mortality is unclear. OBJECTIVE To examine the relationship between TPN and complication and mortality rates in critically ill patients. DATA SOURCES Computerized search of published research on MEDLINE(More)
BACKGROUND The purpose of this project was to describe current nutrition support practice in the critical care setting and to identify interventions to target for quality improvement initiatives. METHODS We conducted a cross-sectional national survey of dietitians working in intensive care units (ICUs) across Canada to document various aspects of(More)
OBJECTIVE To determine the extent to which postpyloric feeding reduces gastroesophageal regurgitation and pulmonary microaspiration in critically ill patients. DESIGN Randomized trial. SETTING A medical/surgical intensive care unit at a tertiary care hospital. PARTICIPANTS Intensive care unit patients were expected to remain ventilated >72 hrs. We(More)
BACKGROUND Strategies that maximize the delivery of enteral nutrition while minimizing the associated risks have the potential to improve the outcomes of critically ill patients. By delivering enteral feeds in the small bowel, beyond the pylorus, the frequency of regurgitation and the risk of aspiration is thought to be decreased while at the same time,(More)