John W Donovan

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Follicular lymphomas (FLs) are neoplastic counterparts of normal germinal center (GC) B cells. FLs are characterized by t(14;18) with deregulation of the Bcl-2 (BCL2) gene. The presence of t(14;18) and overexpression of Bcl-2 is necessary, but not sufficient, to cause this disease. An array containing 588 complementary DNAs (cDNAs) was used to compare the(More)
Both alcohol withdrawal syndrome (AWS) and benzodiazepines can cause delirium. Benzodiazepine-associated delirium can complicate AWS and prolong hospitalization. Benzodiazepine delirium can be diagnosed with flumazenil, a GABA-A receptor antagonist. By reversing the effects of benzodiazepines, flumazenil is theorized to exacerbate symptoms of AWS and(More)
Recently, we read the observation by Walker et al. [1] published in the Journal of Medical Toxicology and commend the authors for their recognition of anticholinergic syndrome. However, we are distressed that a 13-year-old pediatric patient was treated with a novel drug without first having received the known antidote for anticholinergic delirium,(More)
We appreciate the thoughtful comments from Dr Lucyk et al. and the opportunity to clarify and report further details regarding our experience with managing delirium during the course of alcohol withdrawal (AWS). We agree that the treatment of AWS is best managed with symptom-triggered therapy with benzodiazepines, and this is our practice. However, we do(More)
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