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The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of(More)
ProLuCID, a new algorithm for peptide identification using tandem mass spectrometry and protein sequence databases has been developed. This algorithm uses a three tier scoring scheme. First, a binomial probability is used as a preliminary scoring scheme to select candidate peptides. The binomial probability scores generated by ProLuCID minimize molecular(More)
  • M Krüger, S Moser, I Thievessen, C A Luber, F Forner, S Schmidt +88 others
  • 2014
2008. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. 2013. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx(More)
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