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We propose a system based on the Izhikevich model running on a scalable chip multiprocessor - SpiNNaker - for large-scale spiking neural network simulation. The design takes into account the requirements for processing, storage, and communication which are essential to the efficient modelling of spiking neural networks. To gain a speedup of the processing(More)
A fully asynchronous implementation of the ARM microprocessor has been developed in order to investigate the potential of asynchronous logic for low-power applications. The work demonstrates the feasibility of complex asynchronous design and shows that the cost and performance characteristics are similar to clocked designs. AMULET1 is the first attempt at(More)
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As an attempt to improve the predictive nature of this model, integrative bioinformatic approaches were used to(More)
—An asynchronous implementation of the ARM microprocessor has been developed using an approach based on Sutherland's Micropipelines [1]. The design allows considerable internal asynchronous concurrency. This paper presents the rationale for the work, the organization of the chip, and the characteristics of the prototype silicon. The design displays unusual(More)
Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale for the development of Btk inhibitors for treating rheumatoid arthritis (RA). In the present study, we characterized a novel Btk inhibitor,(More)
OBJECTIVE Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR) and Fcγ receptor signaling and is efficacious in animal models of arthritis. The aim of this study was to examine the potential efficacy of BTK in systemic lupus(More)