John V. Smith

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A 25-residue peptide representing the membrane targeting N-terminal splice region of the cyclic AMP phos-phodiesterase RD1 (RNPDE4A1) was synthesized, and its structure was determined by 1 H NMR. Two independently folding helical regions were identified, separated by a highly mobile " hinge " region. The first helical region was formed by an N-terminal(More)
The synthesis and characterization of isotopomer tandem nucleic acid mass tag-peptide nucleic acid (TNT-PNA) conjugates is described along with their use as electrospray ionisation-cleavable (ESI-Cleavable) hybridization probes for the detection and quantification of target DNA sequences by electrospray ionisation tandem mass spectrometry (ESI-MS/MS).(More)
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