John V. Koger

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OBJECTIVE The anterior cingulate cortex has been implicated in depression. Results are best interpreted by considering anatomic and cytoarchitectonic subdivisions. Evidence suggests depression is characterized by hypoactivity in the dorsal anterior cingulate, whereas hyperactivity in the rostral anterior cingulate is associated with good response to(More)
BACKGROUND The frontal lobe has been crucially involved in the neurobiology of major depression, but inconsistencies among studies exist, in part due to a failure of considering modulatory variables such as symptom severity, comorbidity with anxiety, and distinct subtypes, as codeterminants for patterns of brain activation in depression. METHODS Resting(More)
The relationships between brain electrical and metabolic activity are being uncovered currently in animal models using invasive methods; however, in the human brain this relationship remains not well understood. In particular, the relationship between noninvasive measurements of electrical activity and metabolism remains largely undefined. To understand(More)
Methadone maintenance patients are at risk of contracting or transmitting HIV through intravenous drug use and/or unsafe sexual practices. An outcome evaluation of a voluntary AIDS prevention program for methadone patients in three clinics (two experimental, one control) is reported. The prevention program included three components: didactic AIDS education,(More)
In a suburban methadone program, using official police records, a study was made of patients' arrest records before and after methadone treatment. Eighty patients were willing to allow the researchers to secure their arrest records. These 80 patients were similar to the total clinic population of 226 in terms of demographic variables, arrest records, and(More)
The emotional and behavioral responses of methadone patients to HIV antibody testing were examined by comparing 8 seropositives with 8 matched seronegatives. Seropositives displayed a wide range of immediate emotional reactions to learning their results, but no severe or damaging reactions; seronegatives were uniformly relieved. Almost all patients informed(More)
The SCL-90, a psychiatric symptom test, was administered to 264 methadone maintenance treatment program clients. Although patients generally had levels of distress comparable with psychiatric patient populations, no relation between the level of symptom distress and patient performance was found. Female patients were significantly more disturbed than male(More)
This study of 460 patients showed that the 37% of the patients who were terminated as program failures did significantly worse than the active patients in terms of drug abuse, criminality, and social productivity. These findings suggest that methadone maintenance is at best a marginally effective modality for those large numbers of patients who drop out.(More)
Background: The frontal lobe has been crucially involved in the neurobiology of major depression, but inconsistencies among studies exist, in part due to a failure of considering modulatory variables such as symptom severity, comorbidity with anxiety, and distinct subtypes, as codeterminants for patterns of brain activation in depression. Methods: Resting(More)