John Twist

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In this study, methyl- and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure of solvent membrane interaction, gave a good rank order correlation to the flux data for a(More)
In this study the influence of paraben concentration on flux from solution in 1-propanol through polydimethylsiloxane membranes was investigated. Alcohol was sorbed by the polymer membrane leading to changes in membrane dimensions and increased membrane capacity to contain paraben (partition coefficient). Diffusion coefficients were not significantly(More)
The purpose of this study was to define coating conditions for the enteric coating of a highly water soluble, acidic tablet core. Acidic tablet cores containing a marker drug were separated into three groups and seal coated to coverage levels of 0% (uncoated, white), 1% (yellow), and 3% (tan) weight gains. By employing a 'color coding' scheme, the different(More)
To compare sample data from x-ray diffraction a suitable metric is developed to evaluate the similarity (or dissimilarity) between samples and to compare it to a references. The methodology focuses on the d-lines and uses the intensity measurements indirectly in the algorithm. The resulting d-line distribution and summary statistics of the differences is(More)
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