John Timothy Caldwell

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It has been previously shown that acute myeloid leukemia (AML) patients with higher levels of GATA1 expression have poorer outcomes. Furthermore, pediatric Down syndrome (DS) patients with acute megakaryocytic leukemia (AMKL), whose blast cells almost universally harbor somatic mutations in exon 2 of the transcription factor gene GATA1, demonstrate(More)
________________________________ Advisor Date ________________________________ ________________________________ ________________________________ ________________________________ ii DEDICATION This work is dedicated to two (often, but not always, distinct) groups of people. The first is all of those suffering from any sort of debilitating disease. There are(More)
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