John Timothy Caldwell

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Acute myeloid leukemia (AML) remains a challenging disease to treat and urgently requires new therapies to improve its treatment outcome. In this study, we investigated the molecular mechanisms underlying the cooperative antileukemic activities of panobinostat and cytarabine or daunorubicin (DNR) in AML cell lines and diagnostic blast samples in vitro and(More)
Acute myeloid leukemia (AML) is a malignant disease of cells arising from the myeloid lineage. A heterogeneous disease, AML consists of many different subtypes, each with different treatment sensitivities and prognoses. Despite advances in care, AML remains a difficult to treat disease, with overall survival (OS) being approximately 25% and 65% in the adult(More)
High-risk neuroblastoma remains a therapeutic challenge with a long-term survival rate of less than 40%. Therefore, new agents are urgently needed to overcome chemotherapy resistance so as to improve the treatment outcome of this deadly disease. Histone deacetylase (HDAC) inhibitors (HDACIs) represent a novel class of anticancer drugs. Recent studies(More)
BACKGROUND Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, thus enhancing the antitumor activity of DNA damaging agents. In this study, we investigated MK-1775 in AML cell lines and diagnostic blast(More)
It has been previously shown that acute myeloid leukemia (AML) patients with higher levels of GATA1 expression have poorer outcomes. Furthermore, pediatric Down syndrome (DS) patients with acute megakaryocytic leukemia (AMKL), whose blast cells almost universally harbor somatic mutations in exon 2 of the transcription factor gene GATA1, demonstrate(More)
I had no business making a film about this world around me, or so I thought. All my academic training had led me to this conclusion. The suburban migrant camps I visited and studied between 1994 and 2001 in San Diego and Orange counties, California, offered an impressive range of ideological traps that any theory-conscious filmmaker or cultural studies(More)
________________________________ Advisor Date ________________________________ ________________________________ ________________________________ ________________________________ ii DEDICATION This work is dedicated to two (often, but not always, distinct) groups of people. The first is all of those suffering from any sort of debilitating disease. There are(More)
In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the presenting WBC count (< 50,000/cumm vs > 50,000). We(More)
  • Rand Impact Award, Gates Cambridge Scholar, John T Caldwell, Alumni Scholar, Associate Mathematician, Santa Monica +1 other
  • 2013
 Performing research to assist in policy-making, with a specialization in energy and environmental issues. Primary roles have been mathematical modelling, quantitative uncertainty analysis, and risk assessment. Current research includes cost-benefit analysis of flood risk reduction projects in Louisiana, life cycle assessment of greenhouse gas emissions(More)
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