John T. Sinnott

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HTLV-I is a retrovirus now identified as the etiologic agent of two diverse disease processes: ATLL, an aggressive T-cell malignancy; and TSP/HAM, a chronic progressive myelopathy. Transmission can occur horizontally through blood transfusions, IV drug abuse and sexual intercourse. Vertical transmission may also occur. Available diagnostic modalities are(More)
OBJECTIVE To determine the prevalence of lipodystrophy, dyslipidemia, and hyperglycemia among HIV-infected patients taking long-term, first-line, World Health Organization (WHO)-recommended generic highly active antiretroviral therapy (HAART) regimens in India. DESIGN : Cross-sectional study. METHODS Asymptomatic, antiretroviral-naive patients and those(More)
Pneumonia is a common and potentially fatal complication of transplantation. The clinical approach to this problem requires a multipronged attack. Thorough evaluation of the donor and recipient reduces the risk of infection while pointing to likely infectious complications to be anticipated posttransplant. Careful attention to infection control measures(More)
Eleven patients with rapidly progressive herpetic retinal necrosis (RPHRN) complicating AIDS were investigated retrospectively to study the disease spectrum, systemic involvement, and therapy. The mean CD4 cell count was 24/microL. There was a characteristic disease pattern with rapid progression, 82% bilaterality, relative resistance to intravenous(More)
Levamisole is a veterinary anti-helminthic used to treat several autoimmune conditions but also commonly utilized as an additive in cocaine distribution. Toxicity resulting in agranulocytosis and cutaneous necrosis in association with cocaine use is an infrequently described phenomenon of an emerging problem. Although levamisole is found extensively in the(More)
Cryptococcal arthritis remains a rare entity. Crystalline arthropathy has been described in association with bacterial infection, but no similar association has been described for crystalline joint disease and fungal infection. We have described a renal transplant patient with concurrent gout and cryptococcal arthritis that responded favorably to treatment.(More)
We have reported a case of spinal osteomyelitis and empyema caused by Yersinia enterocolitica. Because this patient was in otherwise good health without evidence of liver disease, the extent of her illness was remarkable. This unique report of Y enterocolitica infection of the spine not only illustrates the organism's capacity for hematogenous spread in(More)
Mucormycosis historically has caused substantial morbidity with high mortality in renal transplant patients with disseminated and/or rhinocerebral infection and in patients with gastrointestinal illness regardless of predisposing conditions. We report the first successful treatment of gastric mucormycosis in a renal transplant recipient and review presumed(More)