• Publications
  • Influence
Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner*
RNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) is often increased in cancer cells. Although some data support that PTBExpand
  • 47
  • 3
Synthesis and anticancer activities of 6-amino amonafide derivatives
Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Amonafide contains a free arylamine, which causes it to be metabolizedExpand
  • 38
  • 1
Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancy
The perinucleolar compartment (PNC) is a subnuclear structure localized at the nucleolar periphery. Previous studies using breast cancer as a model system demonstrated that PNC prevalence (theExpand
  • 38
  • 1
The Perinucleolar Compartment Is Directly Associated with DNA*
The perinucleolar compartment (PNC) is a nuclear subdomain that is unique to tumor cells, and the percentage of cells in a population containing PNCs (PNC prevalence) indicates the level ofExpand
  • 24
  • 1
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis in vivo. Blocking metastasis from the inside Metastasis, the spread of tumor cells that oftenExpand
  • 22
  • 1
Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2
There remains a compelling need for the development of treatments for unresectable melanoma. Agents that stimulate the innate immune response could provide advantages for cell-based therapies.Expand
  • 17
  • 1
Automated High-Content Screening for Compounds That Disassemble the Perinucleolar Compartment
All solid malignancies share characteristic traits, including unlimited cellular proliferation, evasion of immune regulation, and the propensity to metastasize. The authors have previously describedExpand
  • 22
  • 1
The perinucleolar compartment: RNA metabolism and cancer.
The perinucleolar compartment (PNC) is a nuclear substructure associated with, but structurally distinct from, the nucleolus. The PNC contains several RNA processing proteins and several RNA pol IIIExpand
  • 11
  • 1
Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.
Amonafide is a DNA intercalator in clinical development for the treatment of cancer. The drug has a 5-position amine that is variably acetylated to form a toxic metabolite in humans, increasingExpand
  • 15
  • PDF
6‐Methoxyethylamino‐numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib
Hepatocellular carcinoma (HCC) is the third leading form of cancer worldwide, and its incidence is increasing rapidly in the United States, tripling over the past 3 decades. The currentExpand
  • 4