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Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been(More)
CONTEXT Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a hereditary abnormality in a DNA mismatch repair (MMR) gene. Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence(More)
Prostate cancer incidence was prospectively studied among 7999 men of Japanese ancestry who were first examined between 1965 and 1968 and then followed through 1986. During this surveillance period, 174 incident cases of prostate cancer were recorded. Prostate cancer was not associated with any measure of socioeconomic status, including amount of education,(More)
OBJECTIVES An understanding of factors associated with interest in genetic counseling and intentions to obtain colorectal cancer susceptibility testing is an important foundation for developing education, counseling, and genetic services and policies. MATERIALS AND METHODS A survey was mailed to first-degree relatives of patients diagnosed with colorectal(More)
Previous studies have suggested that increased physical activity may be protective against colon cancer. Most of these studies measured activity indirectly. The present study evaluated several direct measurements of physical activity and also resting heart rate as determined from an electrocardiogram. Increased activity was consistently associated with a(More)
BACKGROUND Family studies have served as a cornerstone of genetic research on colorectal cancer. MATERIALS AND METHODS The Colorectal Cancer Family Registry (Colon CFR) is an international consortium of six centers in North America and Australia formed as a resource to support studies on the etiology, prevention, and clinical management of colorectal(More)
OBJECTIVES To improve and broaden the applicability of performance-based measures of function for use in clinical and research settings. DESIGN Cross-sectional repeated-measures study. SETTING Research clinic. PARTICIPANTS Population-based sample of Japanese Americans without significant functional impairments aged 35 to 55 and 56 to 71 (N=203). (More)
Recent publications have reported that common variants on 8q24 are associated with both prostate and colorectal cancers (CRC). In addition, one of these studies (the ARCTIC study) initially observed an association with a single nucleotide polymorphism (SNP) on 9p24 that was not confirmed in some of their validation data sets. In the research described here,(More)
FOXO3 is generally recognized as a "master" gene in aging since its association with longevity has been replicated in multiple organisms and human populations. A group of single nucleotide polymorphisms in linkage disequilibrium with a coding region has been associated with human longevity, but the actual functional variant is unidentified. Therefore, we(More)