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Mendel's Accountant (hereafter referred to as " Mendel ") is a user-friendly biologically realistic simulation program for investigating the processes of mutation and selection in sexually reproducing diploid populations. Mendel represents an advance over previous forward-time programs in that it incorporates several new features that enhance biological(More)
Long-standing theoretical concerns about mutation accumulation within the human population can now be addressed with numerical simulation. We apply a biologically realistic forward-time population genetics program to study human mutation accumulation under a wide-range of circumstances. Using realistic estimates for the relevant biological parameters, we(More)
Evolutionary genetic theory has a series of apparent " fatal flaws " which are well known to population geneticists, but which have not been effectively communicated to other scientists or the public. These fatal flaws have been recognized by leaders in the field for many decades—based upon logic and mathematical formulations. However population geneticists(More)
Mendel's Accountant (hereafter referred to as " Mendel ") is a state-of-the-art forward-time population genetics model that tracks millions of individual mutations with their unique effects on fitness and unique location within the genome through large numbers of generations. It treats the process of natural selection in a precise way. It allows a user to(More)
We have calculated the consensus sequence for human mitochondrial DNA using over 800 available sequences. Analysis of this consensus reveals an unexpected lack of diversity within human mtDNA worldwide. Not only is more than 83% of the mitochondrial genome invariant, but in over 99% of the variable positions, the majority allele was found in at least 90% of(More)
Functional information is normally communicated using specific, context-dependent strings of symbolic characters. This is true within the human realm (texts and computer programs), and also within the biological realm (nucleic acids and proteins). In biology, strings of nucleotides encode much of the information within living cells. How do such(More)
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