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  • Kenneth M. Felsenstein, Lindsey B. Saunders, +7 authors John S Schneekloth
  • Biology, Medicine
  • ACS chemical biology
  • 2016 (First Published: 15 January 2016)
  • The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC. One attractiveContinue Reading
  • Joanna Sztuba-Solińska, Shilpa R. Shenoy, +4 authors John S Schneekloth
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 2014 (First Published: 11 June 2014)
  • Identifying small molecules that selectively bind to structured RNA motifs remains an important challenge in developing potent and specific therapeutics. Most strategies to find RNA-binding moleculesContinue Reading
  • Fardokht A Abulwerdi, Matthew D. Shortridge, +4 authors John S Schneekloth
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2016 (First Published: 22 December 2016)
  • Small molecules that bind to RNA potently and specifically are relatively rare. The study of molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV genomic element,Continue Reading