John S. McDonald

Learn More
BACKGROUND The role of the delta-opioid receptor in ethanol drinking has remained unclear despite the use of traditional pharmacological and correlational approaches. The results of several studies suggest that pharmacological blockade of these receptors results in decreases in ethanol drinking behavior, but an approximately equal number of reports have(More)
Opioid peptides long have been hypothesized to play a role in ethanol reinforcement. Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol self-administration in rodents and prevent relapse in humans. However, the exact mechanism for such powerful effects has remained elusive. The availability of mu-opioid receptor(More)
Comparison of 46 handwritten and electromechanically generated blood pressure records revealed substantial differences between the recordings. The highest automated record pressures exceeded the highest pressures found in corresponding handwritten records. Similarly, the lowest pressures from automated records were lower than those from handwritten records.(More)
We have evaluated the effect of an automatic anaesthesia record keeper (AARK) on record keeping time and vigilance. With informed patient consent and institutional approval, we videotaped the attending anaesthetist and his/her immediate surroundings during 66 surgical procedures. Thirty-seven cases were charted manually and the remaining 29 were charted(More)
A time and motion study was made of anaesthetists during 32 surgical procedures. Thirteen activities performed by the anaesthetist were defined for the study. Time and event data were recorded electronically and analysed by digital computer. Activity and link analysis techniques were used to analyse the data. Only 25% of intraoperative time was spent(More)
This study investigated the expression of the N-ras oncogene in routinely processed tissue sections from 133 patients with squamous cell carcinoma of the head and neck (SCCHN) by immunohistochemistryusing anti-N-ras monoclonal antibody. N-ras expression was present in 67 of 133 (49.67%) cases. There was a highly significant correlation between N-ras(More)
We have previously shown that the pre- and postoperative administration of an analgesic dose of morphine attenuated the tumour-enhancing effects of surgery. This study was undertaken to assess the relative role and exclusive importance of pre- versus postoperative morphine administration on neuroendocrine, metastatic, and behavioural outcomes of surgery in(More)
79 male and 16 female residents in anesthesiology at six training centers took the California Psychological Inventory (CPI) and Strong Interest Inventory (SII) in Year 1 and were rated for performance two years later. Descriptively, the total sample scored highest on CPI scales for Dominance, Social Presence, and Achievement via Independence, and on SII(More)