John S. Lowengrub

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A new formulation and new methods are presented for computing the motion of fluid interfaces with surface tension in two-dimensional, irrotational, and incompressible fluids. Through the Laplace-Young condition at the interface, surface tension introduces high-order terms, both nonlinear and nonlocal, into the dynamics. This leads to severe stability(More)
We study solid tumor ( carcinoma) growth in the nonlinear regime using boundary-integral simulations. The tumor core is nonnecrotic and no inhibitor chemical species are present. A new formulation of the classical models [18,24,8,3] is developed and it is demonstrated that tumor evolution is described by a reduced set of two dimensionless parameters and is(More)
We study numerically the simplest model of two incompressible, immiscible fluids shearing past one another. The fluids are two-dimensional, inviscid, irrotational, density matched, and separated by a sharp interface under a surface tension. The nonlinear growth and evolution of this interface is governed by only the competing effects of the Kelvin–Helmholtz(More)
In this paper, we present and investigate a model for solid tumor growth that incorporates features of the tumor microenvironment. Using analysis and nonlinear numerical simulations, we explore the effects of the interaction between the genetic characteristics of the tumor and the tumor microenvironment on the resulting tumor progression and morphology. We(More)
This is the first paper in a two-part series in which we develop, analyze, and simulate a diffuse interface continuum model of multispecies tumor growth and tumor-induced angiogenesis in two and three dimensions. Three-dimensional simulations of nonlinear tumor growth and neovascularization using this diffuse interface model were recently presented in(More)
An axisymmetric numerical method to simulate the dynamics of insoluble surfactant on a moving liquid-fluid interface is presented. The motion of the interface is captured using a volume-of-fluid method. Surface tension, which can be a linear or nonlinear function of surfactant concentration (equation of state), is included as a continuum surface force. The(More)
Despite major scientific, medical and technological advances over the last few decades, a cure for cancer remains elusive. The disease initiation is complex, and including initiation and avascular growth, onset of hypoxia and acidosis due to accumulation of cells beyond normal physiological conditions, inducement of angiogenesis from the surrounding(More)
We extend the diffuse interface model developed in Wise et al. (2008) to study nonlinear tumor growth in 3-D. Extensions include the tracking of multiple viable cell species populations through a continuum diffuse-interface method, onset and aging of discrete tumor vessels through angiogenesis, and incorporation of individual cell movement using a hybrid(More)
In this article, we present a new multiscale mathematical model for solid tumour growth which couples an improved model of tumour invasion with a model of tumour-induced angiogenesis. We perform nonlinear simulations of the multi-scale model that demonstrate the importance of the coupling between the development and remodeling of the vascular network, the(More)
We present an unconditionally energy stable finite-difference scheme for the phase field crystal equation. The method is based on a convex splitting of a discrete energy and is semiimplicit. The equation at the implicit time level is nonlinear but represents the gradient of a strictly convex function and is thus uniquely solvable, regardless of time step(More)