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To enable sophisticated optogenetic manipulation of neural circuits throughout the nervous system with limited disruption of animal behavior, light-delivery systems beyond fiber optic tethering and large, head-mounted wireless receivers are desirable. We report the development of an easy-to-construct, implantable wireless optogenetic device. Our smallest(More)
enormous effort has been devoted to elucidate the nature of these diseases: what is wrong, what is the cause, why are some afflicted while others are not.... ? As the title indicates, Functional Recovery in Neurological Disease takes a slightly different approach and asks: given a damaged nervous system, how does the rest of the system cope with this(More)
The ability to implant electronic systems in the human body has led to many medical advances. Progress in semiconductor technology paved the way for devices at the scale of a millimeter or less ("microimplants"), but the miniaturization of the power source remains challenging. Although wireless powering has been demonstrated, energy transfer beyond(More)
| Efficient wireless power transfer across tissue is highly desirable for removing bulky energy storage components. Most existing power transfer systems are conceptually based on coils linked by slowly varying magnetic fields (less than 10 MHz). These systems have many important capabilities, but are poorly suited for tiny, millimeter-scale implants where(More)
—This paper examines transmitter optimization for wirelessly powering a small implant embedded in tissue. The wireless link between the transmitter and receiver is first modeled as a two-port network and an expression for the power transfer efficiency derived. For a given small receiver in a multilayer tissue model, the transmitter is abstracted as a sheet(More)
Optical or electrical stimulation of neural circuits in mice during natural behavior is an important paradigm for studying brain function. Conventional systems for optogenetics and electrical micros-timulation require tethers or large head-mounted devices that disrupt animal behavior. We report a method for wireless powering of small-scale implanted devices(More)
Alkaline exonuclease and single-strand DNA (ssDNA) annealing proteins (SSAPs) are key components of DNA recombination and repair systems within many prokaryotes, bacteriophages and virus-like genetic elements. The recently sequenced β-proteobacterium Laribacter hongkongensis (strain HLHK9) encodes putative homologs of alkaline exonuclease (LHK-Exo) and SSAP(More)
Idiopathic neuromuscular disease of the gastrointestinal tract (functional bowel disease) is thought to result from the malfunction of neurons within the enteric nervous system. Gonadotropin-releasing hormone (GnRH) analogs have recently been shown to organize the disordered motility patterns typical in these patients and to produce significant, long-term(More)