John S Hamblin

Learn More
Transient receptor potential vanilloid 1 (TRPV1) was shown to modulate hippocampal CA1 pyramidal cell synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Synaptic plasticity is the cellular mechanism thought to mediate declarative learning and memory in the hippocampus. Although TRPV1 is involved in modulating(More)
The paper addresses the general question of identifying the optimum environment for selection in plant breeding programs for low input agricultural systems. After defining low-yielding and high-yielding environments based on the average grain yield of large numbers of barley genotypes in different cropping seasons, we examined: 1) the phenotypic(More)
The effect of bulk breeding on yield and its components was studied in two high-yielding and two low-yielding bean crosses until the F6 generation. It was found that bulk breeding on the whole did not alter the mean values in the high-yielding crosses, but that there was a steady increase in the mean values of the low-yielding crosses with generation. As(More)
We present the estimation of heritabilities of an observed trait in situations where evaluation of several pure breeding lines is performed in a trial at a single location and in trials from several locations. For the single location situation, we evaluate exact confidence intervals, the probability of invalid estimates, and the percentage points of the(More)
BACKGROUND Metformin use has been linked to improved cancer outcomes. The purpose of this study was to determine the impact of metformin on the survival of patients with laryngeal cancer. METHODS We retrospectively reviewed 205 patients with a diagnosis of laryngeal squamous cell carcinoma (SCC). RESULTS Patients taking metformin presented with more(More)
Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI(50)'s of 10(-4)-10(-5) microg/mL, and each compound was(More)
Moving average and polynomial response surfaces were used to estimate systematic micro-environmental variation within four different F3 selection environments. At low density the response surfaces were efficient in estimating systematic variation. At high densities random variation due to intergenotypic competition predominates. It is concluded that the two(More)
By utilizing a bioassay-guided separation (P388 lymphocytic leukemia and a panel of human cancer cell lines) of fermentation broths from a Kitasatospora sp. collected from a tundra soil sample taken at the shore of the Beaufort Sea, we have isolated three powerful (GI50 to 0.0006 microg/mL) cancer cell growth inhibitors (1-3) and determined their structures(More)
Nineteen durum wheat landraces, cultivars or advanced lines of different origins in West Asia and North Africa (WANA), and three barley and two bread wheat varieties were evaluated for their boron (B) toxicity tolerance. Seedlings were grown at five levels of soluble soil B in a plastic house under controlled temperatures. Significant differences existed(More)
The grain yield of F5 lines from a barley cross, grown in field plots, showed no correlation with F3 single plant grain yield. F5 grain yield did however show a significant inverse relationship with plant height and leaf length in the F3, especially at high levels of nitrogen. Shorter plants with shorter leaves in the F3 tended to produce lines of similar(More)