John S. Fossey

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The reversible boronic acid-diol interaction empowers boronic acid receptors' saccharide binding capacities, rendering them a class of lectin mimetic, termed "boronlectins". Boronic acids follow lectin functions not just in being able to bind saccharides, but in multivalent saccharide binding that enhances both affinity and selectivity. For almost a decade,(More)
Boronic acids can interact with Lewis bases to generate boronate anions, and they can also bind with diol units to form cyclic boronate esters. Boronic acid based receptor designs originated when Lorand and Edwards used the pH drop observed upon the addition of saccharides to boronic acids to determine their association constants. The inherent acidity of(More)
A bis-boronic acid modified electrode for the sensitive and selective determination of glucose concentrations has been developed. The electrochemical characteristics of the sensor with added saccharides were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The bis-boronic acid modified electrode was both sensitive(More)
(2014) A water-soluble boronate-based fluorescent probe for the selective detection of peroxynitrite and imaging in living cells. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. A water-soluble boronate-based fl uorescent probe for the selective detection of(More)
Room temperature iodocyclisation of homoallylamines stereoselectively delivers functionalised 2-(iodomethyl)azetidine derivatives in high yield. Increasing reaction temperature from 20 °C to 50 °C switches the reaction outcome to realise the stereoselective formation of functionalised 3-iodopyrrolidine derivatives. It was shown that these pyrrolidines are(More)
BACKGROUND Hydration is a universal phenomenon in nature. The interactions between biomolecules and water of hydration play a pivotal role in molecular biology. 2-Thioxanthine (2TX), a thio-modified nucleic acid base, is of significant interest as a DNA inhibitor yet its interactions with hydration water have not been investigated either computationally or(More)
A facile one-step approach to fabricate substrates for surface-enhanced Raman scattering (SERS) detection of polycyclic aromatic hydrocarbons (PAHs) was explored by reduction of silver nitrate with humic acids (HAs). This simple process readily delivers silver nanoparticles (Ag NPs) decorated with HAs (HAs-Ag NPs), and an average diameter of 50 nm. More(More)