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Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic alpha cells in response to low blood glucose. To examine the role of glucagon in glucose homeostasis, mice were generated with a null mutation of the glucagon receptor (Gcgr(-/-)). These mice display lower blood glucose levels throughout the day and improved glucose tolerance(More)
Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by(More)
Retarded wound healing was found in mice deficient in the serine protease precursor plasminogen, as well as in wild-type mice treated with the metalloprotease inhibitor galardin, but in both cases wound closure was ultimately completed in all mice within 60 days. The expression of several matrix metalloproteases in keratinocytes migrating to cover the wound(More)
The availability of gene-targeted mice deficient in the urokinase-type plasminogen activator (uPA), urokinase receptor (uPAR), tissue-type plasminogen activator (tPA), and plasminogen permits a critical, genetic-based analysis of the physiological and pathological roles of the two mammalian plasminogen activators. We report a comparative study of animals(More)
The association constants of the binding of chlorpromazine and imipramine to serum albumin at low saturation of the protein were determined by a new experimental approach with the protein concentration rather than the ligand concentration being varied. This approach is suitable for estimating binding constants in systems with one class of binding sites. In(More)
The glycolipid-anchored receptor for urokinase-type plasminogen activator (uPAR) is essential for cell-surface associated plasminogen activation and is overexpressed at the invasive tumor-stromal microenvironment in many human cancers. In line with this, uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance(More)
The matrix-inserted surface transplantation model is an in vivo assay used to analyse the kinetics of tumor-vessel interactions during different stages of skin carcinoma progression. This system allows the study of host-tumor interface, i.e. penetration of tumor cells into normal host tissue as well as infiltration of normal host cells into the tumor. In(More)
This book is unique. Such a publishing event has never happened before and will never happen again. John Romer, historian, archaeologist and respected TV presenter has with this new book which has taken five years to write solved the mystery of the Great Pyramid. The Great Pyramid of Giza is the most ancient of the Wonders of the World, in its arrangements(More)
7 8-] ouy-en-] osas RÉSUMÉ On a analysé l'effet de l'âge (1 an, 3 ans, 4 ans) et du niveau de production du troupeau (3 niveaux) sur l'héritabilité des productions laitières de brebis de race Lacaune dans la région de Roquefort (production laitière totale à la traite YL, production au contrôle maxi-muni C. Max). L'analyse a porté au total sur 8 926 couples(More)
Embryo transfer for dairy cattle in the United States has been used most extensively by Holstein-Friesian breeders, with a rapid increase since 1975. Brown Swiss, Jersey, and Red and White breeders also have reported use of embryo transfer recently. Estimated transmitting abilities for embryo donors are above average, although not outstanding, as are(More)