John Robert Phillips

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We examine the coherence in the spontaneous brain activity of sleeping children as measured by the blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signals. The results are described in terms of resting-state networks (RSN) and their properties. More specifically, in this study we examine the effect of severe prematurity(More)
Thinning of the posterior sclera may imply that stretching and/or weakening of the sclera plays a role in axial elongation of myopic eyes. We investigated the elastic stress-strain properties of sclera from developing tree shrew eyes made myopic by monocular deprivation (MD) of form vision. Five days of MD induced a relative myopia (mean +/- SEM) of -5.6 D(More)
AIM To evaluate the acceptability, effectivity, and side effects of a monovision spectacle correction designed to reduce accommodation and myopia progression in schoolchildren. METHODS Dominant eyes of 11 year old children with myopia (-1.00 to -3.00 D mean spherical equivalent) were corrected for distance; fellow eyes were uncorrected or corrected to(More)
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder that can affect every organ of the body, most commonly the brain, kidneys, heart, and lungs. The TSC mutation results in abnormal cellular proliferation and differentiation, which are responsible for hamartomatous lesions that affect the brain, kidney, heart, and lungs. mTOR(More)
PURPOSE To investigate the role of scleral creep in the axial elongation of chick and tree shrew eyes with induced myopia. METHODS Form-deprivation myopia was induced with a diffusing occluder worn over one eye. Scleral samples from the posterior pole and equatorial regions of myopic, contralateral (control), and age-matched normal chick and tree shrew(More)
PURPOSE To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression. DESIGN Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS Dual-Focus(More)
exhibit white matter (WM) injury on clinical MRI scans, not all do, and it often isn’t until later school age that cognitive deficits become evident (Anderson and Doyle, 2003). Because earlier treatment is generally more effective for neurocognitive problems associated with prematurity, a method of more accurately identifying those children at risk for(More)
PURPOSE To describe the time-course and amplitude of changes to sub-foveal choroidal thickness (SFCT) induced by imposed hyperopic and myopic retinal defocus and to compare the responses in emmetropic and myopic subjects. METHODS Twelve East Asian subjects (age: 18-34 years; six were emmetropic and six had myopia between -2.00 and -5.00 dioptres (D))(More)
PURPOSE To investigate the change in axial eye dimensions resulting from stretching the sclera by acute elevation of intraocular pressure (IOP). METHODS IOP was increased to 100 mm Hg for 1 hour through an intravitreal cannula, while ocular component dimensions were monitored every 10 minutes with A-scan ultrasound in anesthetized animals (10 chicks and(More)
PURPOSE To determine whether the distribution of naturally occurring myopia in Labrador Retrievers has a genetic component. METHODS Pedigree records of a large canine family were analyzed. Pure Labrador Retrievers, 1 to 8 years of age, free of ocular disease, and available for testing were studied. Refractive error was measured by cycloplegic retinoscopy(More)