John Riddell

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To effectively study the mechanisms by which deep brain stimulation (DBS) produces its therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS over an extended period of time in awake, freely behaving animals. To date multiple preclinical stimulators have been designed and described. However, these stimulators have(More)
AIM To prospectively determine the role of platelet glycoprotein IIIa (GP IIIa) gene PlA1/PlA2 polymorphism on the long-term clinical outcome in patients with coronary artery disease undergoing coronary stenting. DESIGN AND SETTING Prospective observational study in the University Hospital of Caen (France). PATIENTS AND METHODS 1 111 symptomatic(More)
The reproducibility of focussed ultrasound-induced intra-articular pain was compared with that of electrically induced cutaneous pain over a period of time by measuring both the evoked potential (EP) amplitude and visual analogue scale (VAS) score. The responses to ultrasound were more variable than those to electrical stimulation. A greater degree of(More)
BACKGROUND Noninvasive assessment of coronary atherosclerotic plaque and significant stenosis by coronary multidetector computed tomography (MDCT) may improve early and accurate triage of patients presenting with acute chest pain to the emergency department. METHODS AND RESULTS We conducted a blinded, prospective study in patients presenting with acute(More)
Alinidine is a new drug which reduces heart-rate in animals by an unknown mechanism. Oral administration of 40 and 80 mg significantly reduced an exercise tachycardia in healthy people, with small reductions in heart-rate in the standing and supine positions. Alinidine 80 mg reduced arterial pressure in the standing and supine positions. The reduction in(More)
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