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  • John R. Vane, Yeshwant S Bakhle, R M Botting
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1998 (First Publication: 1 April 1998)
  • Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a productExpand
  • Timothy D Warner, Fiorella Giuliano, Ivana Vojnović, Antoaneta Bukasa, Jane A Mitchell, John R. Vane
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 22 June 1999)
  • The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition ofExpand
  • Jane A Mitchell, Pravit Akarasereenont, Christoph Thiemermann, Roderick John Flower, John R. Vane
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1993 (First Publication: 15 December 1993)
  • Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, andExpand