John R. Raye

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There is controversy in the literature regarding the prognostic value of the EEG following neonatal seizures. This report reviews the results of a prospective study comparing EEG findings and outcome in 74 term and preterm infants following neonatal seizures. EEGs were evaluated for both background rhythms and epileptiform activity. Outcome was evaluated at(More)
The pharmacokinetics of furosemide were studied longitudinally during long-term administration in 10 very low birth weight infants with bronchopulmonary dysplasia. Mean birth weight of the infants was 829 +/- 217 g, mean gestational age at birth was 26.6 +/- 2.9 weeks, and mean postnatal age at the start of therapy was 2.4 +/- 1.0 weeks. Serial(More)
Umbilical blood flow and fetal oxygen, glucose, lactate, and pyruvate uptakes were measured in the chronically catheterized fetal lamb subsequent to administration of morphine sulfate to the mother (0.66 mg/kg). No significant change in umbilical blood flow or fetal oxygen consumption was noted during the 120-minute observation period. Although transient(More)
Insulin may be an important regulator of growth in late fetal life. To assess the importance of endogenous insulin release in regulation of normal fetal growth, eight fetal lamb pairs were given either an intravenous injection of streptozocin (STZ), a nitrosourea that selectively damages pancreatic beta-cells, or buffer infusion (controls). In six(More)
The daily sodium requirement in very low birth weight infants is unknown. For this reason, sodium balance was studied in 16 consecutive neonates weighing <1200 grams at birth. Group I, 12 infants <30 weeks gestational age (955 ± 35 gms.); Group II, 4 infants >30 weeks gestational age (997 ± 78 gms.). Weight, sodium and fluid intake, and serum sodium were(More)
To determine whether multiple doses of bovine surfactant would improve neonatal mortality in very premature neonates, we conducted two multicenter controlled trials under identical protocols; the results were combined for analysis. Four hundred and thirty neonates born between 23 and 29 weeks gestation and weighing 600 to 1250 g at birth were assigned(More)
ABSTRACT. Antenatal maternal glucocorticoid administration has been widely used to accelerate fetal lung maturation. Glucocorticoids have also been used postnatally selected neonates as antiinflammatory agents. Numerous studies have shown that glucocorticoids inhibit multiple components of the immune system including neutrophil (PMN) function in children(More)
Summary: Acute glucagon injections were performed in chronically catfa-eterized fetal lambs in late gestation to assess the fetal metabolic response to exogenous glucagon infusion. Glucagon dosages between 1 ug/kg and 1 mg/kg induced significant fetal hyperglycemia by 15–30 min postinjection, with peak glucose values 130–180% of control. Increasing(More)