John R. North

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We show that an innate defense-regulator peptide (IDR-1) was protective in mouse models of infection with important Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Salmonella enterica serovar Typhimurium. When given from 48 h before to 6 h after infection, the peptide(More)
Innate defense regulator-1 (IDR-1) is a synthetic peptide with no antimicrobial activity that enhances microbial infection control while suppressing inflammation. Previously, the effects of IDR-1 were postulated to impact several regulatory pathways including mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein, but how this was(More)
Innate Defense Regulators (IDRs) are short synthetic peptides that target the host innate immune system via an intracellular adaptor protein which functions at key signaling nodes. In this work, further details of the mechanism of action of IDRs have been discovered. The studies reported here show that the lead clinical IDR, SGX94, has broad-spectrum(More)
We have used the Sydney University Stellar Interferometer (SUSI) to measure the angular diameter of β Hydri. This star is a nearby G2 subgiant whose mean density was recently measured with high precision using asteroseismology. We determine the radius and effective temperature of the star to be 1.814± 0.017 R⊙ (0.9%) and 5872± 44 K (0.7%) respectively. By(More)
The triple system HD158926 (λSco) has been observed interferometrically with the Sydney University Stellar Interferometer and the elements of the wide orbit have been determined. These are significantly more accurate than the previous elements found spectroscopically. The inclination of the wide orbit is consistent with the inclination previously found for(More)
BACKGROUND & AIMS A gluten-containing diet alters bowel barrier function in patients with irritable bowel syndrome with diarrhea (IBS-D), particularly those who are positive for HLA allele DQ2/8. We studied the effects of a gluten-free diet (GFD) in patients with IBS-D who have not previously considered the effects of gluten in their diet and were unaware(More)
A new photosensitizer, presently designated QLT0074, may have the potential for the treatment of immune and nonimmune conditions with photodynamic therapy (PDT). The activity of QLT0074 was tested against human peripheral blood T cells and Jurkat T lymphoma cells. At low nanomolar concentrations of QLT0074 in combination with blue light, apoptosis was(More)
The first complete orbital solution for the double-lined spectroscopic binary system γ 2 Velorum, obtained from measurements with the Sydney University Stellar Interferometer (SUSI), is presented. This system contains the closest example of a Wolf-Rayet star and the promise of full characterisation of the basic properties of this exotic highmass system has(More)
We have used the Sydney University Stellar Interferometer to measure the angular diameter of α Cir. This is the first detailed interferometric study of a rapidly oscillating A (roAp) star, α Cir being the brightest member of its class. We used the new and more accurate Hipparcos parallax to determine the radius to be 1.967 ± 0.066 R . We have constrained(More)