John R. McPherson

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This paper examines the issues surrounding distributed Digital Library protocols. First, it reviews three prominent digital library protocols: Z39.50, SDLIP, and Dienst, plus Greenstone's own protocol. Then, we summarise the implementation in the Greenstone Digital Libary of a number of different protocols for distributed digital libraries, and describe(More)
Managing the organizational and software complexity of a comprehensive open source digital library system presents a significant challenge. The challenge becomes even more imposing when the interface is available in different languages, for enhancements to the software and changes to the interface must be faithfully reflected in each language version. This(More)
Greenstone is a suite of software for building and distributing digital library collections. It provides a new way of organizing information and publishing it on the Internet or on CD-ROM. Greenstone is produced by the New Zealand Digital Library Project at the University of Waikato, and developed and distributed in cooperation with UNESCO and the Human(More)
This report examines various aspects of the use of computers for the purpose of displaying sheet music for musicians. The main focus is on the layout of the displayed music and methods that can be used to simulate physical page turning to provide new information for the musician. The techniques that may be used to update the field of view depend on factors(More)
Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to(More)
Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure with surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis and normal tissues to characterize genomic progression in 18 patients with(More)
Exposure to environmental mutagens is an important cause of human cancer, and measures to reduce mutagenic and carcinogenic exposures have been highly successful at controlling cancer. Until recently, it has been possible to connect the chemical characteristics of mutagens to actual mutations observed in human tumors only indirectly. Now, next-generation(More)
Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene product neurofibromin is a negative regulator of the Ras cellular proliferation pathway, and also exerts tumour suppression via other mechanisms. Recent next-generation sequencing projects have(More)