John R. McPherson

Learn More
This paper examines the issues surrounding distributed Digital Library protocols. First, it reviews three prominent digital library protocols: Z39.50, SDLIP, and Dienst, plus Greenstone's own protocol. Then, we summarise the implementation in the Greenstone Digital Libary of a number of different protocols for distributed digital libraries, and describe(More)
Managing the organizational and software complexity of a comprehensive open source digital library system presents a significant challenge. The challenge becomes even more imposing when the interface is available in different languages, for enhancements to the software and changes to the interface must be faithfully reflected in each language version. This(More)
Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to(More)
Exposure to environmental mutagens is an important cause of human cancer, and measures to reduce mutagenic and carcinogenic exposures have been highly successful at controlling cancer. Until recently, it has been possible to connect the chemical characteristics of mutagens to actual mutations observed in human tumors only indirectly. Now, next-generation(More)
Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure with surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis and normal tissues to characterize genomic progression in 18 patients with(More)
Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene product neurofibromin is a negative regulator of the Ras cellular proliferation pathway, and also exerts tumour suppression via other mechanisms. Recent next-generation sequencing projects have(More)
This paper investigates attributes of the electronic display of sheet music necessary for the development of a digital music stand. We explore the two conflicting goals of minimising page turning effort and maximising the read-ability of images by conducting two user experiments. In our first experiment participants trialed various page turning methods(More)
The use of audio queries for searching multimedia content has increased rapidly with the rise of music information retrieval; there are now many Internet-accessible systems that take audio queries as input. However, testing the robustness of such a system can be problematic , as there is currently no standard test-bed of queries and music files available. A(More)
Dacomitinib, an irreversible pan-HER inhibitor, had shown modest clinical activity in squamous cell carcinoma of head and neck (SCCHN) patients. Therefore, validated predictive biomarkers are required to identify patients most likely to benefit from this therapeutic option. To characterize the genetic landscape of cisplatin-treated SCCHN genomes and(More)