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Selective inhibition of the low Km cyclic AMP-specific phosphodiesterase has been shown to inhibit inflammatory cell function and relax airway smooth muscle. These studies were conducted to characterize the bronchodilator and anti-inflammatory activity of rolipram, an archetypical cyclic AMP-specific phosphodiesterase inhibitor, in in vitro and in vivo(More)
The effects of six leukotriene (LT) antagonists on LTC4-, D4- and E4-induced contraction of isolated guinea-pig tracheal spirals were examined. Concentration-response effects of the leukotrienes were determined by cumulative addition in the presence of indomethacin (5 microM) alone for LTE4, or with 10 mM of either glutathione or L-cysteine to inhibit(More)
This study uses out-of-sample equity value estimates to determine whether earnings disaggregation, imposing valuation model linear information (LIM) structure, and separate industry estimation of valuation model parameters aid in predicting contemporaneous equity values. We consider three levels of earnings disaggregation: aggregate earnings, cash flow and(More)
Leukotrienes C4 (LTC) and D4 (LTD) produced contractions of the isolated guinea-pig pulmonary arteries, but were much less potent in these segments than in the isolated trachea and parenchymal strip from the same species. Among the arterial segments, the leukotrienes were more effective in contracting the distal end of the main pulmonary artery than the(More)
Cumulative dose-response curves to leukotriene C4 (LTC4) and leukotriene D4 (LTD)4 were obtained on indomethacin (5 microM) treated isolated guinea pig tracheal spiral strips. LTC4 curves, in the presence of either glutathione (GSH; 10 mM) or L-serine borate (SB; 45 mM), were not antagonized by FPL-55712 (3 microM), a selective LTD4 receptor antagonist.(More)
Tracheal strips were obtained from guinea pigs actively sensitized to chicken ovalbumin (OA). OA-induced contractile responses, obtained by cumulative log addition, were found to be comparable both temporally and in magnitude with responses obtained by single addition of OA. The concentration-response curve obtained by cumulative addition of OA was(More)
Contractile responses to histamine were examined on left pulmonary arterial rings isolated from reserpine-pretreated guinea pigs. In the presence of mepyramine, contractile responses to histamine dihydrochloride and histamine diphosphate were preceded by concentration-dependent relaxant responses which were not blocked by metiamide. Hydrochloric acid also(More)