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- John P Ward, John R King, Adrian J Koerber, Julie M Croft, R Elizabeth Sockett, Paul Williams
- Journal of mathematical biology
- 2003

We develop mathematical models to examine the formation, growth and quorum sensing activity of bacterial biofilms. The growth aspects of the model are based on the assumption of a continuum of bacterial cells whose growth generates movement, within the developing biofilm, described by a velocity field. A model proposed in Ward et al. (2001) to describe… (More)

- John P Ward, John R King
- Mathematical biosciences
- 2003

In this paper we adapt an avascular tumour growth model to compare the effects of drug application on multicell spheroids and on monolayer cultures. The model for the tumour is based on nutrient driven growth of a continuum of live cells, whose birth and death generates volume changes described by a velocity field. The drug is modelled as an externally… (More)

- John A. Fozard, Mikaël Lucas, John R. King, Oliver E. Jensen
- Front. Plant Sci.
- 2013

New tools are required to address the challenge of relating plant hormone levels, hormone responses, wall biochemistry and wall mechanical properties to organ-scale growth. Current vertex-based models (applied in other contexts) can be unsuitable for simulating the growth of elongated organs such as roots because of the large aspect ratio of the cells, and… (More)

- Greg Lemon, Daniel Howard, Matthew J Tomlinson, Lee D Buttery, Felicity R A J Rose, Sarah L Waters +1 other
- Mathematical biosciences
- 2009

We present a mathematical model for the vascularisation of a porous scaffold following implantation in vivo. The model is given as a set of coupled non-linear ordinary differential equations (ODEs) which describe the evolution in time of the amounts of the different tissue constituents inside the scaffold. Bifurcation analyses reveal how the extent of… (More)

Many solid tumour growth models are formulated as systems of parabolic and/or hyperbolic equations. Here an alternative, two-phase theory is developed to describe solid tumour growth. Versions of earlier models are recovered when suitable limits of the new model are taken. We contend that the multi-phase approach represents a more general, and natural,… (More)

- Benjamin Péret, Alistair M Middleton, Andrew P French, Antoine Larrieu, Anthony Bishopp, Maria Njo +20 others
- Molecular systems biology
- 2013

In Arabidopsis, lateral roots originate from pericycle cells deep within the primary root. New lateral root primordia (LRP) have to emerge through several overlaying tissues. Here, we report that auxin produced in new LRP is transported towards the outer tissues where it triggers cell separation by inducing both the auxin influx carrier LAX3 and cell-wall… (More)

BACKGROUND
Stochastic and asymptotic methods are powerful tools in developing multiscale systems biology models; however, little has been done in this context to compare the efficacy of these methods. The majority of current systems biology modelling research, including that of auxin transport, uses numerical simulations to study the behaviour of large… (More)

- Leah R Band, Darren M Wells, Antoine Larrieu, Jianyong Sun, Alistair M Middleton, Andrew P French +19 others
- Proceedings of the National Academy of Sciences…
- 2012

Gravity profoundly influences plant growth and development. Plants respond to changes in orientation by using gravitropic responses to modify their growth. Cholodny and Went hypothesized over 80 years ago that plants bend in response to a gravity stimulus by generating a lateral gradient of a growth regulator at an organ's apex, later found to be auxin.… (More)

In this paper we consider the effects of a single anticancer agent on the growth of a solid tumour in the context of a simple mathematical model for the latter. The tumour is assumed to comprise a single cell population which reproduces and dies at a rate dependent on the local drug concentration. This causes cell movement and so establishes a velocity… (More)