John R. Bristol

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Alpha-D-glucopyranose,3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-1-(dihydrogen phosphate), tetrasodium salt (E5564) is a second-generation synthetic lipodisaccharide designed to antagonize the toxic effects of endotoxin, a major(More)
Lipid A from the photosynthetic bacterium Rhodobacter sphaeroides (RSLA) has been previously shown to antagonize many of the effects of endotoxins from more pathogenic gram-negative bacteria. We have reported on the synthesis of the proposed structure of RSLA and determined that bacterially derived RSLA is not identical to its proposed structure (W.J.(More)
Interspecific interactions between Nippostrongylus brasiliensis and Eimeria nieschulzi were studied by measuring parasite fecundity and patency in rats concurrently infected with both species. Nine groups of five rats each were inoculated with either 4 x 10(3) N. brasiliensis larvae or 2.6 x 10(5) E. nieschulzi sporulated oocysts or both. Groups 1 and 2(More)
Taenia solium and T. saginata are zoonotic tapeworms of substantial medical and economic importance. Although human taeniasis is widely recognised as an endemic problem in Mexico, its presence in the United States is poorly understood. The first population-based study to estimate the prevalence of human infection with Taenia tapeworms along the Texas-Mexico(More)
Seventy of 72 green-winged teal, Anas crecca, from southwest Texas were infected with parasites. Seventeen species of endoparasites were recorded: Notocotylus attenuatus, Zygocotyle lunata, Typhlocoelum sisowi, Echinostoma revolutum, Hypoderaeum conoideum, Dendritobilharzia pulverulenta, Cloacotaenia megalops, Sobolevicanthus gracilis, Sobolevicanthus(More)
1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cytokines and other cellular mediators. As part of a program aimed at developing a therapeutic agent for septic(More)
p38 is a member of the mitogen-activated protein (MAP) kinase family. Activation (phosphorylation) of p38 acts as a switch for the transcriptional and translational regulation of a number of proteins, including the proinflammatory cytokines. Investigation of a set of small peptides revealed that, as with protein substrates, p38-alpha behaves as a(More)
Lipid As from non-toxic bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides have been shown to antagonize the immunostimulatory effects of lipid A and LPS from pathogenic bacteria. We have biologically characterized a series of synthetic LPS antagonists including the proposed structures of the lipid A and R. sphaeroides containing fatty acid(More)
Glucose absorption and net small intestinal water movement were examined in rats infected with Nippostrongylus brasiliensis at Days 4, 6, 9, 13, and 19 after inoculation. Rats were infected with 4 X 10(3) N. brasiliensis third stage larvae. The entire small intestine was divided into three segments and each segment perfused simultaneously in vivo with(More)
Eimeria separata is a rat coccidian that parasitizes the caecal epithelial cells. A closely related coccidian, Eimeria nieschulzi, infects rat jejunal enterocytes and has been shown to suppress the self-cure phenomenon associated with an infection by the intestinal nematode, Nippostrongylus brasiliensis (Bristol et al. 1983; Upton et al. 1987). The ability(More)