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As islet transplantation becomes an acceptable clinical modality for restoring normoglycemia in type 1 diabetic patients, there is a crucial need for noninvasive assessment of the fate of the grafts. In spite of the success of the Edmonton Protocol, a significant graft loss occurs due to immunological and nonimmunological events immediately after(More)
BACKGROUND Pancreatic islet transplantation has recently emerged as a powerful clinical modality to restore normoglycemia in diabetic patients. Despite the success of the Edmonton protocol, these patients still experience a significant islet loss immediately after transplantation. Noninvasive magnetic resonance imaging (MRI) allows for longitudinal(More)
Human mesenchymal stromal cells (hMSC) can be used as a drug delivery vehicle for the treatment of GBM. However, tracking the migration and distribution of these transplanted cells is necessary to interpret therapeutic efficacy. We compared three labeling techniques for their ability to track the migration of transplanted hMSC in an orthotopic mouse(More)
Kenneth Arrow and John Pratt established principles for understanding risk and decision making that often directly inform experimental designs today (Arrow 1965; Pratt 1964). However, “real life” decisions involving risk are not as clearly defined as they are in this early economic theory, or the corresponding experiments. As argued by Ellsberg (1961), the(More)
We revisit Kuhn’s classic theorem on mixed and behavior strategies in games. We frame Kuhn’s work in terms of two questions in decision theory: What is the relationship between global and local assessment of uncertainty? What is the relationship between global and local optimality of strategies? This note is a homage to Kuhn’s classic theorem on the(More)