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The clinical data and the imaging findings of the positron emission tomography (PET) and the magnetic resonance imaging (MRI) studies in five patients, previously diagnosed to have propionic acidemia, were retrospectively reviewed. The patients were all normal at birth. The first clinical signs, typically hypotonia and failure to thrive, appeared during the(More)
The clinical, PET (positron emission tomography) and MRI (magnetic resonance imaging) findings of brain studies in eight patients, previously diagnosed to have glutaric aciduria type 1, were retrospectively reviewed. The neurological findings typically consisted of variable degrees of dementia and extrapyramidal symptoms (dystonia, choreoathetosis and(More)
A 33-year-old woman presented with a 3-year history of progressive numbness in the hand, cerebellar ataxia, limb weakness, nystagmus, and dysarthria. T2-weighted MRI revealed abnormal foci of increased signal intensity mimicking demyelinating plaques in the periventricular white matter, and brain 18FDG-PET scan showed increased uptake in the pons. Biopsy(More)
The clinical, 18fluorodeoxyglucose positron emission tomography (18FDG PET) and the magnetic resonance imaging (MRI) brain scan characteristics of four patients diagnosed to have 3-methylglutaconic aciduria were reviewed retrospectively. The disease has a characteristic clinical pattern. The initial presentations were developmental delay, hypotonia, and(More)
We evaluated six methods for CT­CT registration for SPECT­guided radiotherapy treatment planning: affine registration with manual marking of corresponding control points either on the skin or interior to the lung, automatic rigid registration and three deformable registration methods (B­Spline, Demons and Level set). According to the registration results,(More)
A 2-year, 6-month-old Saudi male with infantile Krabbe's disease was studied with fluorine-18-labeled-2-fluoro-2-deoxyglucose positron emission tomography (FDG PET) scan. The patient presented with a gradual loss of developmental milestones, irritability, and crying. At the advanced stage of the disease, he developed tonic-clonic seizures and became a(More)
Purpose: To quantitatively evaluate the accuracy of several SPECT/CT image registration methods in recent studies and its impact on the functional lung volume segmentation in SPECT guided radiation therapy (RT) treatment planning. Methods and Materials: Five lung cancer patients were consented to have a perfusion SPECT scan with 99mTc-macroaggregated(More)
A 30-year-old woman presented with a progressive neurologic disorder characterized by seizures, buccolingual dyskinesias, orofacial tics, choreiform movements, atrophy, and areflexia. Investigations revealed normal lipid profile except for aprebetalipoproteinemia. Phase-contrast and electron microscopy showed 35 to 40% acanthocytes. MRI and(More)
BACKGROUND Post-radiotherapy nasopharyngeal changes represent a diagnostic dilemma. Early detection of persistent or recurrent disease may be translated to better cure rate if salvage therapy is implemented. Neither clinical exam nor current radiological anatomical studies (CT/MRI) can differentiate between benign post therapy changes and recurrence. PET(More)