7Nino Künzli
7Frank Gilliland
Learn More
Associations have been found between long-term exposure to ambient air pollution and cardiovascular morbidity and mortality. The contribution of air pollution to atherosclerosis that underlies many cardiovascular diseases has not been investigated. Animal data suggest that ambient particulate matter (PM) may contribute to atherogenesis. We used data on 798(More)
Results from studies of traffic and childhood asthma have been inconsistent, but there has been little systematic evaluation of susceptible subgroups. In this study, we examined the relationship of local traffic-related exposure and asthma and wheeze in southern California school children (5-7 years of age). Lifetime history of doctor-diagnosed asthma and(More)
  • Nino Künzli, Michael Jerrett, Raquel Garcia-Esteban, Xavier Basagaña, Bernardo Beckermann, Frank Gilliland +4 others
  • 2010
BACKGROUND Cross-sectional studies suggest an association between exposure to ambient air pollution and atherosclerosis. We investigated the association between outdoor air quality and progression of subclinical atherosclerosis (common carotid artery intima-media thickness, CIMT). METHODOLOGY/PRINCIPAL FINDINGS We examined data from five double-blind(More)
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that(More)
The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of(More)
BACKGROUND Traffic-related air pollution has been associated with adverse cardiorespiratory effects, including increased asthma prevalence. However, there has been little study of effects of traffic exposure at school on new-onset asthma. OBJECTIVES We evaluated the relationship of new-onset asthma with traffic-related pollution near homes and schools. (More)
BACKGROUND The question of whether air pollution contributes to asthma onset remains unresolved. OBJECTIVES In this study, we assessed the association between asthma onset in children and traffic-related air pollution. METHODS We selected a sample of 217 children from participants in the Southern California Children's Health Study, a prospective cohort(More)
Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricle surface gliosis is associated with(More)