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OBJECTIVE Transplant rejection remains a clinical problem despite therapies that focus on lymphocyte suppression, with little attention focused on the neutrophil. Neutrophils are however the first leukocyte to infiltrate the allograft, are capable of causing myocardial damage and may facilitate lymphocytes recruitment. We hypothesised that an early(More)
BACKGROUND Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16(More)
Cardiovascular disease is the leading cause of death worldwide. It remains one of the greatest challenges to global health and will continue to dominate mortality trends in the future. Acute myocardial infarction results in 7.4 million deaths globally per annum. Current management strategies are centered on restoration of coronary blood flow via(More)
Thoracoscopy has been a part of thoracic surgical practice for many years. The introduction of the camera chip and newer instrumentation has awakened a new interest in this technique and led to the development of video-assisted thoracic surgery (VATS). One hundred and seventy consecutive procedures performed on 158 patients are reviewed. Video-assisted(More)
All patients presenting to a regional unit with oesophageal carcinoma over a twelve month period are reviewed and the role of transhiatal oesophagectomy for tumours of the middle third of the intrathoracic oesophagus is evaluated. Of the 28 cases of oesophageal carcinoma, 22 (78%) were resected by blunt transhiatal oesophagectomy, the remaining six (22%)(More)
Using video thoracoscopic techniques in 30 patients over a twelve month period we have been able to perform 33 procedures that would have been previously performed by thoracotomy, with its associated morbidity. We have found the applications of this procedure to be diverse, being both diagnostic (n = 16) and therapeutic (n = 17). The diagnostic procedures(More)
OBJECTIVE Postoperative acute kidney injury is a frequent and serious consequence of cardiac surgery. We undertook to investigate the association of obesity and the risk of acute kidney injury development after cardiac surgery. METHODS A total of 432 patients who underwent cardiac surgery with cardiopulmonary bypass between October 2009 and August 2010(More)
OBJECTIVE Congenital tracheobronchial obstruction (TBO) presents a complex problem both in terms of diverse aetiology, presence of associated anomalies and the operative strategy to be adopted. We report a single centre experience in managing this difficult problem. METHODS Twenty-four infants and children with TBO referred to our unit over a 12-year(More)