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OBJECTIVE To examine the maternal and foetal risks of adverse pregnancy outcome in relation to maternal obesity, expressed as body mass index (BMI, kg/m(2)) in a large unselected geographical population. DESIGN Retrospective analysis of data from a validated maternity database system which includes all but one of the maternity units in the North West(More)
BACKGROUND Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterized by short episodes of involuntary movement attacks triggered by sudden voluntary movements. Although a genetic basis is suspected in idiopathic cases, the gene has not been discovered. Establishing strict diagnostic criteria will help genetic studies. METHODS The authors(More)
We carried out a review of published, peer-reviewed articles to assess the evidence for effectiveness of control measures during norovirus outbreaks in enclosed settings. There were 47 papers identified for review, some of which reported more than one outbreak, providing 72 outbreaks for analysis. We extracted the following data items: attack rates; the(More)
Over a 30-month period from July 1995 to December 1997, new detections of methicillin-resistant Staphylococcus aureus (MRSA) were prospectively studied in a tertiary referral hospital. The aims of the study were to determine the incidence of colonization of patients admitted to each of the hospital's 39 clinical units and ascertain where each patient had(More)
Percutaneous Silastic catheters (PSCs) are used in premature infants to deliver total parenteral nutrition. We report two cases in which migration of the catheter into the right atrium resulted in rapid onset of shocklike symptoms. Pericardial effusion and tamponade were diagnosed by echocardiography. Subxiphoid pericardiocenteses were performed, with(More)
The obstetric risks of adverse outcome during pregnancy in women aged > or =35 years were quantified using a retrospective analysis of data from 385 120 singleton pregnancies in the North West Thames Region, UK, between 1988 and 1997. A comparison of pregnancy outcome was made on the basis of maternal age at delivery: 18-34 years (n = 336 462), 35-40 years(More)
PURPOSE The aim of this study was to compare the outcome of consecutive patients with abdominal aortic aneurysm (AAA) treated concurrently by open operation and endoluminal intervention by the same surgeons during a defined interval. METHODS Between May 1992 and May 1996, 362 consecutive patients with AAA underwent repair. Fifty-three patients who(More)
OBJECTIVE To determine the maternal and fetal risk of adverse outcome during pregnancy in relation to low maternal body mass index in an unselected population. DESIGN Retrospective analysis. METHODS Information for the years between 1988 and 1997 was extracted from a validated maternity database, including all but one of the maternity units in the North(More)
OBJECTIVES To identify demographic risk factors for either birthweight >4kg or over the 90th centile and to quantify the obstetric risks. STUDY DESIGN Data from 350,311 completed singleton pregnancies in the North West Thames Region between 1988 and 1997 were analysed using logistic regression. Predisposing factors and pregnancy outcome were compared by(More)
Although the technical success and short-term efficacy of endovascular grafts have now been demonstrated, the long-term durability of grafts used in the aorta remains to be proven. No long-term data are yet available regarding device durability or patient outcome beyond the initial few years. Recent evidence shows that the ability of endovascular grafts to(More)