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The Informatics for Integrating Biology and the Bedside (i2b2) is one of the sponsored initiatives of the NIH Roadmap National Centers for Biomedical Computing (http://www.bisti.nih.gov/ncbc/). One of the goals of i2b2 is to provide clinical investigators broadly with the software tools necessary to collect and manage project-related clinical research data(More)
Judging from the excited rhetoric of some of its enthusiasts, health information technology (HIT) has the power to transport us to almost a dream-like world of health care perfection in which the work of doctors and the care of patients proceed with barely imaginable quality and efficiency. For many physicians, however, especially those in solo or small(More)
Tens of thousands of subjects may be required to obtain reliable evidence relating disease characteristics to the weak effects typically reported from common genetic variants. The costs of assembling, phenotyping, and studying these large populations are substantial, recently estimated at three billion dollars for 500,000 individuals. They are also(More)
OBJECTIVE To assess the ability to identify potential association(s) of diabetes medications with myocardial infarction using usual care clinical data obtained from the electronic medical record. RESEARCH DESIGN AND METHODS We defined a retrospective cohort of patients (n = 34,253) treated with a sulfonylurea, metformin, rosiglitazone, or pioglitazone in a(More)
A graduate-level course introducing healthcare professionals to healthcare information systems, their design, development and implementation, as well as human factor considerations important to their success. Course Objective To give healthcare professionals a practical understanding of healthcare information systems sufficient to work effectively with and(More)
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