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Galanthamine was determined in plasma and tissue extracts of mice, after the application of 4, 6 and 8 mg/kg (i.v.), by reverse phase HPLC, with fluorescence detection. A biexponential decline of concentrations in plasma, with a terminal half-life of 43.3 min, was observed after the dose of 4 mg/kg. The volume of distribution (Vss) of 2.17 l/kg was similar(More)
OBJECT Head trauma is a dynamic process characterized by a cascade of metabolic and molecular events. Erythropoietin (EPO) has been shown to have neuroprotective effects in animal models of traumatic brain injury (TBI). Acute in vivo mechanisms and pathological changes associated with EPO following TBI are unknown. In this study the authors compare acute(More)
The action of galanthamine (GAL), a cholinesterase inhibiting substance, on resting EEG and on flash visual evoked potentials (VEPs) was tested in 9 healthy subjects. Alpha power was increased significantly in 4 of 8 subjects after the infusion of 10 mg, which provided a median inhibition of 47% of acetylcholinesterase in erythrocytes. Mean alpha frequency(More)
BACKGROUND The authors assess the risk and safety profiles of both implant and autologous breast reconstructions in the morbidly obese population using the National Surgical Quality Improvement Program data sets. METHODS The authors reviewed the 2005 to 2010 National Surgical Quality Improvement Program databases, identifying encounters for Current(More)
OBJECTIVES Incisional hernia (IH) remains a common, highly morbid, and costly complication. Modest progress has been realized in surgical technique and mesh technology; however, few advances have been achieved toward understanding risk and prevention. In light of the increasing emphasis on prevention in today's health care environment and the billions in(More)
BACKGROUND Perforator flaps minimize abdominal site morbidity during autologous breast reconstruction. The purpose of this study was to assess whether the number of perforators harvested influences the overall deep inferior epigastric perforator (DIEP) flap survival and flap-related complications. METHODS A retrospective review was performed of all DIEP(More)
were given a diuretic which does not improve the condition. One-third of patients resided outside of our local referral area. The average time between onset of lymphedema and referral to our Lymphedema Program was 10 years (range, <1–62 years). ConCluSionS: Patients presenting to a center with " lymphedema " often have another condition, and may be(More)
METHODS: Patients who underwent Exparel injection and On-Q implantation following autologous reconstruction were reviewed. Primary outcome measures included: Patient Controlled Analgesia (PCA) dose/frequency/ attempts/rejections, daily pain score, required oral postop-erative pain medication, and return-to-ambulation. Postop-erative oral pain medications(More)
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