John P. Doyle

David P. Toczyski2
Daniel Durocher1
2David P. Toczyski
1Daniel Durocher
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  • Genevieve M. Vidanes, Frédéric D. Sweeney, Sarah Galicia, Stephanie Cheung, John P. Doyle, Daniel Durocher +1 other
  • 2010
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression. The process of adaptation occurs when cells are presented with persistent or irreparable DNA damage and escape the cell-cycle arrest imposed by the DNA damage checkpoint. However, the precise(More)
Levels of G1 cyclins fluctuate in response to environmental cues and couple mitotic signaling to cell cycle entry. The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast. Cln3 degradation is essential for proper cell cycle control; however, the mechanisms that control Cln3 degradation are largely unknown. Here we show that(More)
In this demo, we will demonstrate usage of NLM Video Search, open-source software which facilitates the dissemination of video content by combining traditional web video playback controls with on-demand seeking using text selected from a corresponding transcript (see Figure 1). NLM Video Search has been implemented in NLM's Fedora-based digital repository,(More)
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