John P. DaVanzo

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Described herein is the effect of several drug classes on suppressing isolation-induced fighting behavior. A diverse group of drugs was found to have an inhibitory effect on this form of behavior. Also included is our method of assay adapted from the work of others in which training and isolation are combined to produce agonistic behavior. This increases(More)
Administration of aminooxyacetic acid (AOAA) and γ-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h(More)
Two classical tricyclic antidepressants possessing anticholinergic side effects, amitriptyline and desipramine, were compared to newer antidepressants lacking such activity, mianserin, trazodone, and bupropion, for their ability to inhibit muricidal behavior. As has been previously shown for the tricyclic antidepressants, the newer antidepressants without(More)
The influence of isolation was studied on the development of muricidal behavior and on brain GABA. GABA was significantly lower in several parts of the limbic system of brain taken from muricidal rats, when compared to their non-muricidal counterparts. Isolation potentiated the development of muricidal behavior and lowered GABA levels. Administration of(More)
Mouse killing by rats represents a predatory behavior that can be modified by drugs from several different therapeutic classes and by environmental conditions. Buspirone and gepirone, non-benzodiazepine anxiolytics that stimulate serotonergic receptors (5HT1a) and inhibit isolation-induced intraspecies aggression, were tested for inhibition of muricidal(More)
Flutamide (FTA), an anti-androgenic compound, inhibited the effects of methyltestosterone (MT) on the weight of the ventral prostate, seminal vesicles and levator ani in male castrate mice. Castration prevented the development of aggressive behavior in mice isolated for 3 weeks. While chronic administration of MT to castrate isolated mice returned the(More)