John P. Bechara

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The trans-activating response of DNA/RNA-binding protein (TDP)-43 pathology is associated with many neurodegenerative diseases via unknown mechanisms. Here, we use a transgenic mouse model over-expressing human wild-type neuronal TDP-43 to study the effects of TDP-43 pathology on glutamate metabolism and synaptic function. We found that neuronal TDP-43(More)
Time is a ubiquitous but often omitted variable in career selection decisions. This study investigates the impact of temporal elements on career selection decisions, thus advancing our understanding of both career decision making, and timing on decision making. We investigate the influence of timing and duration of experience with career options on career(More)
This paper develops and tests a multi-level organization contingency theory for designing headquarters-subsidiary relations. We use frontier analysis to overcome problems that have hampered advancements in organizational contingency theory in general, and headquarters-subsidiary relationships in particular. Based on a longitudinal study of a large medical(More)
This paper empirically examines the relative performance and adaptiveness of generalist and specialist organizational designs in changing fitness landscapes over time. We apply Data Envelopment Analysis (DEA) to examine the organization design and performance of primary care medical clinics that serve a broad or narrow range of patient needs. DEA enables us(More)
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